![]() ![]() Full list of covariates included in propensity score models and assessment periodsĮTable 3. ![]() Outcome definitions for neurodevelopmental disordersĮTable 2. Additional methods and results for the sibling analysesĮTable 1. ADHD indicates attention-deficit/hyperactivity disorder ASD, autism spectrum disorder.ĮMethods. Counts for the sibling analysis are based on families that had discordance on both antidepressant exposure status and outcome timing. Event counts for all adjusted analyses are based on the cohort after trimming of nonoverlapping regions of the propensity scores. Results from the crude and adjusted analysis using the 80% sample of the referent cohort were very similar to the main results. The high-dimensional propensity score (HDPS) analysis used an 80% random sample of the unexposed cohort in the Medicaid Analytic eXtract data owing to sample size constraints in the SAS macro (SAS Institute) used for HDPS analysis. For the discontinuer referent analysis, the referent is defined as antidepressant dispensing in the 31 to 90 days prior to LMP but no dispensing from 30 days prior to LMP through the day prior to delivery. ![]() For all analyses except the discontinuer referent, the referent is defined as no antidepressant dispensing from 90 days prior to last menstrual period (LMP) through 1 day prior to delivery. The exposed cohort is measured by antidepressant dispensing in late pregnancy. ![]()
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